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Nature. 1987 Nov 5-11;330(6143):41-6.

Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme.

Author information

1
Department of Physics, University of Oregon, Eugene 97403.

Abstract

Measurements of changes in structure and stability caused by 13 different substitutions for threonine 157 in phage T4 lysozyme show that the most stable lysozyme variants contain hydrogen bonds analogous to those in the wild-type enzyme and that structural adjustments allow the protein to be surprisingly tolerant of amino-acid substitutions.

PMID:
3118211
DOI:
10.1038/330041a0
[Indexed for MEDLINE]

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