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Nanomedicine (Lond). 2019 Jun;14(12):1521-1531. doi: 10.2217/nnm-2018-0116. Epub 2019 Jun 10.

Preparation and characterization of nano amitriptyline hydrochloride particles by spray freeze drying.

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Key Laboratory of Advanced Functional Materials of Nanjing, Nanjing Xiaozhuang University, Nanjing 211171, PR China.
Institute of Chemical Materials, China Academy of Engineering Physics (CAEP), Mianyang 621900, PR China.
Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, PR China.
Sichuan Co-Innovation Center for New Energetic Materials, Southwest University of Science & Technology (SWUST), Mianyang 621010, PR China.
Pine Ridge Laboratory of Advanced Materials, Sichuan Easy Scientific Research Community Technology Co., Ltd, Mianyang 621050, PR China.


Aim: To investigate the enhancement of bioavailability by the usage of drug nanoparticles for increasing the efficacy of antidepressant therapeutic value. Materials & methods: Nano-amitriptyline HCI (AMT·HCl) particles were successfully prepared via a simple spray freeze drying (SFD) method. Results: The as-prepared nanoparticles are amorphous instead of crystalline. The mean size of AMT·HCl nanoparticles is 90 nm. In in vitro evaluation, AMT·HCl nanoparticles have greatly improved the dissolution compared with pure bulk materials, which have potential for enhancing human bioavailability and diminishing toxic effect. A nanoparticle formation mechanism was also proposed. Conclusion: These findings promote the development of antidepressant therapeutic evaluation based on the usage of AMT·HCl nanoparticles by SFD method and indicate that SFD is an alternative for a range of nanoparticle preparation in industrial pharmacy.


evaluation; amitriptyline hydrochloride; antidepressants; bioavailability; nanocrystals; spray freeze drying


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