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Tissue Eng Part B Rev. 2019 Jun 10. doi: 10.1089/ten.TEB.2019.0106. [Epub ahead of print]

The dental pulp stem/progenitor cells-mediated inflammatory-regenerative axis.

Author information

1
Christian-Albrechts-Universitat zu Kiel, 9179, Clinic for Conservative Dentistry and Periodontology, Kiel, Schleswig-Holstein, Germany.
2
Cairo University, 63526, Oral Medicine and Periodontology, Giza, Egypt ; karim.fawzy@gmail.com.
3
Newgiza University, 485624, Giza, Giza, Egypt ; relsalawy@ngu.edu.eg.
4
Newgiza University, 485624, Giza, Giza, Egypt ; nibrahim@ngu.edu.eg.
5
Newgiza University, 485624, Giza, Giza, Egypt ; mgadalla@ngu.edu.eg.
6
Newgiza University, 485624, Giza, Giza, Egypt ; halbargasy@ngu.edu.eg.
7
Newgiza University, 485624, Giza, Giza, Egypt ; nzahra@ngu.edu.eg.
8
Newgiza University, 485624, Giza, Giza, Egypt ; smokhtar@ngu.edu.eg.
9
Newgiza University, 485624, Giza, Giza, Egypt ; nelnahhas@ngu.edu.eg.
10
Newgiza University, 485624, Giza, Giza, Egypt ; yelkaliouby@ngu.edu.eg.
11
Christian-Albrechts-Universit├Ąt Kiel, Germany, Clinic for Conservative Dentistry and Periodontology, Kiel, Germany ; doerfer@konspar.uni-kiel.de.

Abstract

Relying on their ease of isolation and remarkable tissue reparative/regenerative potential, dental pulp stem/progenitor cells (DPSCs) gained pronounced importance in the field of regenerative dentistry. Though inflammation is classically considered the reason for the damage of the dentin-pulpal complex, it continues to be an essential stage of any dentin-pulpal tissue repair or regeneration procedures. During their performance of a pulpal tissue repair or regeneration actions, DPSCs interact with their inflammatory micro-environment locally, possibly influencing their fate and the result of any DPSCs-mediated dentin-pulpal reparative/regenerative endeavor. Hence, the present review aims to comprehensively elaborate on these complex interactions of DPSCs with their local pulpal inflammatory microenvironment, particularizing on the inflammatory aspects, affecting DPSCs' stemness, homing/migration, proliferation, differentiation as well as immunomodulation characteristics, the potentially fundamental intra-cellular processes involved and their anticipated association with the non-canonical as well as canonical Wnt/╬▓-Catenin intracellular signaling.

PMID:
31179893
DOI:
10.1089/ten.TEB.2019.0106

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