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Clin Infect Dis. 2019 Jun 8. pii: ciz486. doi: 10.1093/cid/ciz486. [Epub ahead of print]

Changes in Bone Mass After Discontinuation of Pre-Exposure Prophylaxis (PrEP) with Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113.

Author information

1
Department of Pediatrics, Medical College of Wisconsin/Children's Hospital of Wisconsin, Milwaukee, WI, USA.
2
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
3
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
4
Westat, Rockville, MD, USA.
5
Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
6
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
7
Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
8
Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA.
9
Department of Medicine, University of California at San Francisco, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA.

Abstract

HIV-seronegative men who have sex with men aged 15-22 years who lost bone mineral density (BMD) during TDF/FTC PrEP experienced partial or full BMD recovery 48 weeks following PrEP discontinuation, except lumbar spine and whole body BMD Z-scores remained below baseline 48 weeks off PrEP in participants aged 15-19 years.

KEYWORDS:

adolescents; bone mineral density; men who have sex with men; preexposure prophylaxis; tenofovir disoproxil fumarate

PMID:
31179503
DOI:
10.1093/cid/ciz486

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