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J Orthop Res Ther. 2019;10(1). pii: 1127. doi: 10.29011/2575-8241.001127. Epub 2019 Jan 31.

Vitamin C in Cancer Therapeutics and Metastasis.

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National Cancer Institute, Division of Cancer Treatment and Diagnosis, Office of Cancer Complementary and Alternative Medicine, Rockville, USA.


There have been significant increased publications of preclinical studies and clinical trials of vitamin C (ascorbate) on cancer therapeutics in the past a few years. In this communication reflecting my personal opinions, I will highlight the main points of current research status; discuss impacts of vitamin C on immune cell function and inflammation at tumor microenvironment, and tumor metastasis; and propose stimulating questions and direction for future research in this area.

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