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Vet Comp Oncol. 2019 Jun 8. doi: 10.1111/vco.12512. [Epub ahead of print]

Clinical outcomes, ultrastructure, and immunohistochemical features of canine high-grade olfactory neuroblastoma.

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Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine.
University of Pennsylvania, School of Veterinary Medicine.
Department of Pathology, Microbiology, and Immunology, University of California at Davis, School of Veterinary Medicine.


Olfactory neuroblastoma (ONB) is a rare intranasal neoplasm in both dogs and humans. Similar clinical presentation and overlapping histologic and immunohistochemical features of ONB with other intranasal neoplasms can make diagnosis and treatment of intranasal neoplasia challenging. Furthermore, in part because of their rarity, there is a lack of reporting on therapeutic regimen for these neoplasms. In humans, initial debulking surgery is usually followed by radiation therapy. Here we report on the histologic, immunohistochemical, and ultrastructural characteristics of canine ONB and report on the clinical progression of cases treated with radiation therapy. In all 9 canine ONB examined here, neoplastic cells were arranged in a lobular manner amidst a prominent neurofibrillary matrix and had features consistent with Grade III (high grade) ONB. The neoplastic cells demonstrated positive staining for TuJ-1, a Class III beta-tubulin neuronal cytoskeletal protein, and variable staining for other markers, including chromogranin, synaptophysin, AE1/AE3, and MAP2. The longest surviving case was treated with a regimen similar to that used in humans, consisting of debulking surgery followed by definitive radiation therapy. Our study found that TuJ-1 is a useful marker for ONB and that radiation therapy, even in cases of advanced disease, may result in prolonged survival. This article is protected by copyright. All rights reserved.


Comparative Oncology; TuJ-1; canine nasal tumors; esthesioneuroblastoma; olfactory neuroblastoma; radiotherapy


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