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J Alzheimers Dis. 2019;70(1):11-15. doi: 10.3233/JAD-190363.

Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation.

Author information

1
Department of Internal Medicine and Medical Specialities, DIMI, Section of Geriatrics, Genoa, Italy.
2
Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.
3
Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
4
Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy.

Abstract

Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355 S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.

KEYWORDS:

Behavioral variant; presenile dementia; presenilin 1 mutation

PMID:
31177233
DOI:
10.3233/JAD-190363

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