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Gynecol Oncol. 2019 Jun 5. pii: S0090-8258(19)31277-6. doi: 10.1016/j.ygyno.2019.05.032. [Epub ahead of print]

Recurrent ovarian immature teratoma in a 12-year-old girl: Implications for management.

Author information

1
Department of Gynaecologic Oncology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom of Great Britain and Northern Ireland.
2
Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom of Great Britain and Northern Ireland.
3
Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom of Great Britain and Northern Ireland.
4
Department of Paediatric Surgery, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom of Great Britain and Northern Ireland.
5
Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom of Great Britain and Northern Ireland.
6
Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom of Great Britain and Northern Ireland; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom of Great Britain and Northern Ireland. Electronic address: mjm16@cam.ac.uk.

Abstract

Immature teratomas (IT) are rare and recurrences uncommon. A 12-year-old female with grade 3 (high-grade) ovarian IT underwent surgical resection but experienced early recurrences; the first was treated with surgery but the second was metastatic and managed with chemotherapy, resulting in growing-teratoma-syndrome and need for further surgery. She now remains well in uneventful clinical follow-up. We believe chemotherapy could be reserved for very carefully selected recurrent IT cases, which may alter the natural history of disease.

KEYWORDS:

Chemotherapy; Germ cell tumor; Growing teratoma syndrome; Gynecologic oncology; Immature teratoma; Ovarian; Pediatric oncology; Surgery

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