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J Infect Chemother. 2019 Jun 5. pii: S1341-321X(19)30141-2. doi: 10.1016/j.jiac.2019.05.009. [Epub ahead of print]

Acute ischemic colitis with hematochezia related to baloxavir marboxil treatment for influenza A.

Author information

1
Niiza Hospital, Department of Pharmacy, 3-14-30, Horinouchi, Niiza, Saitama, 352-0023, Japan. Electronic address: n8_kanai@yahoo.co.jp.
2
Niiza Hospital, Department of Pharmacy, 3-14-30, Horinouchi, Niiza, Saitama, 352-0023, Japan. Electronic address: h.taka@zb.cyberhome.ne.jp.
3
Niiza Hospital, Department of Internal Medicine, 3-14-30, Horinouchi, Niiza, Saitama, 352-0023, Japan. Electronic address: m_fukuda02@tmg.or.jp.
4
Niiza Hospital, Department of Gastroenterological Surgery, 3-14-30, Horinouchi, Niiza, Saitama, 352-0023, Japan. Electronic address: tsj5255md@yahoo.co.jp.

Abstract

Oseltamivir, an established oral anti-influenza medication, increases the risk of ischemic colitis. Baloxavir marboxil is a novel oral anti-influenza medication, and few studies have evaluated its potential side effects, including ischemic colitis. Moreover, as influenza A can also induce ischemic colitis, drug-induced colitis associated with anti-influenza medication is not clearly understood. In this report, we describe the case of a 62-year-old Japanese woman who developed acute ischemic colitis after taking baloxavir for influenza A. The day after taking baloxavir (day 2), the patient experienced abdominal pain, diarrhea, and nausea. On day 3, she had developed hematochezia and decided to visit our hospital. Upon presentation, inflammation of the descending and sigmoid colon was detected by abdominal echography and computed tomography. Fluid replacement therapy and dietary restrictions were initiated. On day 4, the inflammation of the descending colon and marked intestinal edema were confirmed by colonoscopy. She was clinically diagnosed with ischemic colitis, from which she recovered completely by day 9. This case suggests that patients taking baloxavir may be at risk of developing ischemic colitis with hematochezia and underscores the need to further study the induction of this condition by commonly used oral anti-influenza agents.

KEYWORDS:

Acute ischemic colitis; Baloxavir marboxil; Hematochezia; Influenza A

PMID:
31176533
DOI:
10.1016/j.jiac.2019.05.009

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