Solid Stress in Brain Tumors

Daniele M Gilkes; Denis Wirtz

doi:10.1016/j.trecan.2019.03.003

Solid Stress in Brain Tumors

Trends Cancer. 2019 May;5(5):266-268. doi: 10.1016/j.trecan.2019.03.003. Epub 2019 Apr 8.

Authors

Daniele M Gilkes¹, Denis Wirtz²

Affiliations

¹ Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Physical Sciences in Oncology Center, and Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: dgilkes1@jhu.edu.
² Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Physical Sciences in Oncology Center, and Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.

PMID: 31174838
DOI: 10.1016/j.trecan.2019.03.003

Abstract

A solid brain tumor mass places compressive forces on adjacent normal brain tissue, and clinically presents as impaired motor performance in cancer patients, ultimately limiting their quality of life. In a recent article by Jain and colleagues (Nat. Biomed. Eng. 2019;3:230-245), the biological consequences of mechanical forces imparted by a growing tumor mass are explored in both mouse models and human brain tumors, revealing a novel opportunity for therapeutic intervention.

Publication types

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MeSH terms

Animals
Brain
Brain Neoplasms*
Disease Models, Animal
Humans
Lithium*
Mice
Quality of Life

Substances

Lithium

Abstract

Publication types

MeSH terms

Substances

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