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Comp Immunol Microbiol Infect Dis. 2019 Jun;64:153-158. doi: 10.1016/j.cimid.2019.03.004. Epub 2019 Mar 8.

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period.

Author information

1
First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China. Electronic address: 369168231@qq.com.
2
Cell Biology and Genetics Department, Shantou University Medical College, Shantou, 515041, China; Department of Biochemistry, Medical College of Jiaying University, Meizhou, 514031, China. Electronic address: 13592849398@163.com.
3
Cell Biology and Genetics Department, Shantou University Medical College, Shantou, 515041, China. Electronic address: phe@stu.edu.cn.
4
Cell Biology and Genetics Department, Shantou University Medical College, Shantou, 515041, China. Electronic address: 742795693@qq.com.
5
Cell Biology and Genetics Department, Shantou University Medical College, Shantou, 515041, China. Electronic address: kecw1965@aliyun.com.
6
Cell Biology and Genetics Department, Shantou University Medical College, Shantou, 515041, China. Electronic address: xyjiao@stu.edu.cn.

Abstract

PURPOSE:

The etiology of community-acquired pneumonia (CAP) in hospital patients is often ambiguous due to the limited pathogen detection. Lack of a microbiological diagnosis impairs precision treatment in CAP.

METHODS:

Specimens collected from the lower respiratory tract of 195 CAP patients, viruses were measured by the Single-plex real-time PCR assay and the conventional culture method was exploited for bacteria.

RESULTS:

Among the 195 patients, there were 46 (23.59%) pure bacterial infections, 20 (10.26%) yeast infections, 32 (16.41%) pure viral infections, 8 (4.10%) viral-yeast co-infections, and 17 (8.72%) viral-bacterial co-infections. The two most abundant bacteria were Acinetobacter baumannii and klebsiella pneumoniae, whereas the most common virus was influenza A.

CONCLUSIONS:

Non-influenza respiratory microorganisms frequently co-circulated during the epidemic peaks of influenza, which easily being ignored in CAP therapy. In patients with bacterial and viral co-infections, identifying the etiologic agent is crucial for patient's therapy.

KEYWORDS:

Co-infections; Community-acquired pneumonia; Influenza; Respiratory virus; bacterial/Yeast infection

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