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Curr Opin Neurobiol. 2019 Jun 4;59:79-86. doi: 10.1016/j.conb.2019.04.006. [Epub ahead of print]

The chromatin landscape of neuronal plasticity.

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Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10065, USA.
Department of Genetics, Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA. Electronic address:


Examining the links between neuronal activity, transcriptional output, and synaptic function offers unique insights into how neurons adapt to changing environments and form memories. Epigenetic markers, such as DNA methylation and histone modifications, have been implicated in the formation of not only cellular memories such as cell fate, but also memories of experience at the organismal level. Here, we review recent advances in chromatin regulation that contribute to synaptic plasticity and drive adaptive behaviors through dynamic and precise regulation of transcription output in neurons. We discuss chromatin-associated proteins, histone variant proteins, the contribution of cis-regulatory elements and their interaction with histone modifications, and how these mechanisms are integrated into distinct behavior and environmental response paradigms.


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