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Bioinformatics. 2019 Jun 7. pii: btz465. doi: 10.1093/bioinformatics/btz465. [Epub ahead of print]

vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.

Author information

1
Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
2
Computational Biology Life Sciences Group, Barcelona Supercomputing Centre, Barcelona, Spain.

Abstract

MOTIVATION:

Genetic alterations lead to tumor progression and cell survival but also uncover cancer-specific vulnerabilities on gene dependencies that can be therapeutically exploited.

RESULTS:

vulcanSpot is a novel computational approach implemented to expand the therapeutic options in cancer beyond known-driver genes unlocking alternative ways to target undruggable genes. The method integrates genome-wide information provided by massive screening experiments to detect genetic vulnerabilities associated to tumors. Then, vulcanSpot prioritizes drugs to target cancer-specific gene dependencies using a weighted scoring system based on well known drug-gene relationships and drug repositioning strategies.

AVAILABILITY:

http://www.vulcanspot.org.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

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