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Gates Open Res. 2019 Feb 12;3:131. doi: 10.12688/gatesopenres.12897.1. eCollection 2019.

Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination.

Author information

1
Department of Medicine,, University of California San Francisco, San Francisco, CA, USA.
2
Consultant to UNITAID, Denver, CO, USA.
3
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
4
PATH, Seattle, WA, USA.
5
London School of Tropical Medicine & Hygiene, London, UK.
6
The Burnet Institute, Melbourne, Australia.
7
Intellectual Ventures, Bellevue, WA, USA.
8
Centers of Disease Control and Prevention, Atlanta, GA, USA.
9
Clinton Health Access Initiative (CHAI), Boston, MA, USA.
10
FIND, Geneva, Switzerland.
11
Center for Applied Malaria Research and Evaluation, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.
12
Institut Pasteur, Paris, France.
13
Tropical Medicine Foundation Dr. Heitor Viera Dourado, Manaus, Amazonas, Brazil.
14
Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
#
Contributed equally

Abstract

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;  and testing and treating P. vivax hypnozoite carriers.

KEYWORDS:

Elimination; Malaria; Serology; Use Cases

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