Format

Send to

Choose Destination
Science. 2019 Jun 7;364(6444):948-951. doi: 10.1126/science.aax0164.

Self-organization of stem cells into embryos: A window on early mammalian development.

Author information

1
Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ms2261@cam.ac.uk siggiae@rockefeller.edu mz205@cam.ac.uk.
2
Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10065, USA. ms2261@cam.ac.uk siggiae@rockefeller.edu mz205@cam.ac.uk.
#
Contributed equally

Abstract

Embryonic development is orchestrated by robust and complex regulatory mechanisms acting at different scales of organization. In vivo studies are particularly challenging for mammals after implantation, owing to the small size and inaccessibility of the embryo. The generation of stem cell models of the embryo represents a powerful system with which to dissect this complexity. Control of geometry, modulation of the physical environment, and priming with chemical signals reveal the intrinsic capacity of embryonic stem cells to make patterns. Adding the stem cells for the extraembryonic lineages generates three-dimensional models that are more autonomous from the environment and recapitulate many features of the pre- and postimplantation mouse embryo, including gastrulation. Here, we review the principles of self-organization and how they set cells in motion to create an embryo.

PMID:
31171690
DOI:
10.1126/science.aax0164

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center