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Trends Neurosci. 2019 Sep;42(9):566-568. doi: 10.1016/j.tins.2019.05.004. Epub 2019 Jun 3.

Studying Laboratory Mice - Into the Wild.

Author information

1
Neurosciences Axis, Centre de recherche du CHU de Québec, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada.
2
Neurosciences Axis, Centre de recherche du CHU de Québec, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada. Electronic address: tremblay.marie-eve@crchudequebec.ulaval.ca.

Abstract

Studies using rewilded laboratory mice have begun to provide important clues into the complex relationship between environment, immunity, and behavior. In a recent paper, Cope and colleagues (Hippocampus, 2019) showed that exposing laboratory mice to outdoor living, either with or without peripheral worm infection, increased adult neurogenesis and had major effects on microglia, but only outdoor living coupled with worm infection increased anxiety.

KEYWORDS:

anxiety; microglia; neurogenesis; phagocytosis

PMID:
31171382
DOI:
10.1016/j.tins.2019.05.004

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