Format

Send to

Choose Destination
Hepatology. 2019 Jun 6. doi: 10.1002/hep.30804. [Epub ahead of print]

Childhood socioeconomic disadvantage and risk of fatty liver in adulthood: the Cardiovascular Risk in Young Finns Study.

Author information

1
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Centre for Population Health Research, University of Turku and Turku University HospitalTurku, Finland.
2
Paavo Nurmi Centre, Sports& Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland.
3
Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland.
4
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
5
Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland.
6
Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland, Department of Epidemiology and Public Health, University College London, London, UK.
7
Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
8
Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.
9
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
10
Department of Pediatrics, Oulu University Hospital, PEDEGO Research Unit and MRC Oulu, University of Oulu, Oulu, Finland.
11
Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
12
Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.
13
Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland.

Abstract

Fatty liver is a preventable cause of liver failure, but early risk factors for adulthood fatty liver are poorly understood. We examined the association of childhood socioeconomic disadvantage with adulthood fatty liver and tested adulthood risk factors of fatty liver as possible mediators of this link. The study population comprised 2,042 participants aged 3-18 years at baseline (1980) from the longitudinal Cardiovascular Risk in Young Finns Study. Follow-up with repeated clinical examinations was 31 years. Childhood socioeconomic disadvantage was assessed using data from parents' socioeconomic position and socioeconomic circumstances in participants' residential neighborhoods, categorized as high versus low socioeconomic disadvantage. Fatty liver was determined by ultrasound during the last follow up (2011) at ages 34-49 years. Childhood and adulthood risk factors, including metabolic biomarkers and life-style variables, were assessed in clinical examinations. 18.9% of the participants had fatty liver in adulthood. High childhood socioeconomic disadvantage was associated with an increased risk of fatty liver (risk ratio[95% confidence interval] 1.42[1.18-1.70],P=0.0002). This association was robust to adjustment for age, sex, and childhood risk factors of fatty liver, including high body mass index, elevated insulin, and low birth weight (1.33[1.09-1.62],P=0.005). High childhood socioeconomic disadvantage was also associated with the development of risk factors of fatty liver in adulthood. Adulthood risk factors linking childhood socioeconomic disadvantage with fatty liver included waist circumference (proportion mediated of the total effect of childhood socioeconomic disadvantage 45%), body mass index (40%), systolic blood pressure (29%), insulin (20%), physical activity (15%), triglycerides (14%), and red meat consumption (7%). CONCLUSION: Childhood socioeconomic disadvantage was associated with multiple risk factors of fatty liver and increased likelihood of fatty liver in adulthood. This article is protected by copyright. All rights reserved.

KEYWORDS:

Hepatic steatosis; Longitudinal study; Population study; Risk factors; Socioeconomic status

PMID:
31169929
DOI:
10.1002/hep.30804

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center