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J Cancer Res Ther. 2019 Jul-Sep;15(3):725-728. doi: 10.4103/jcrt.JCRT_1044_16.

Inflammatory myofibroblastic tumor of the oral cavity: A case report and literature review.

Author information

1
Department of Oral Pathology and Microbiology, School of Dentistry, D. Y. Patil University, Mumbai, Maharashtra, India.
2
Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, Maharashtra, India.

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare tumor of unknown etiology and pathogenesis. The lesion has been recognized to occur at various sites but rarely affects the head and neck region. A 29-year-old male presented with a 13 months' history of a slow growing, painless growth in maxillary left posterior gingiva. An excisional biopsy was performed under local anesthesia. Microscopic examination revealed a compact cellular spindle cell proliferation with collagenous stroma having storiform architecture. Immunohistochemistry revealed that the tumor cells were positive for smooth muscle actin, CD-68 and negative for anaplastic lymphoma kinase. Oral IMT should be included in the differential diagnosis of localized gingival enlargement mimicking oral hyperplastic/reactive lesions.

KEYWORDS:

Inflammatory myofibroblastic tumor; myofibroblasts; oral cavity

PMID:
31169252
DOI:
10.4103/jcrt.JCRT_1044_16
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