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J Cancer Res Ther. 2019 Jul-Sep;15(3):725-728. doi: 10.4103/jcrt.JCRT_1044_16.

Inflammatory myofibroblastic tumor of the oral cavity: A case report and literature review.

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Department of Oral Pathology and Microbiology, School of Dentistry, D. Y. Patil University, Mumbai, Maharashtra, India.
Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, Maharashtra, India.


Inflammatory myofibroblastic tumor (IMT) is a rare tumor of unknown etiology and pathogenesis. The lesion has been recognized to occur at various sites but rarely affects the head and neck region. A 29-year-old male presented with a 13 months' history of a slow growing, painless growth in maxillary left posterior gingiva. An excisional biopsy was performed under local anesthesia. Microscopic examination revealed a compact cellular spindle cell proliferation with collagenous stroma having storiform architecture. Immunohistochemistry revealed that the tumor cells were positive for smooth muscle actin, CD-68 and negative for anaplastic lymphoma kinase. Oral IMT should be included in the differential diagnosis of localized gingival enlargement mimicking oral hyperplastic/reactive lesions.


Inflammatory myofibroblastic tumor; myofibroblasts; oral cavity

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