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J Int Med Res. 2019 Jun 6:300060519850392. doi: 10.1177/0300060519850392. [Epub ahead of print]

New local treatment for photoaging using a formulation containing piroxicam 0.8% and sunscreen.

Author information

1
1 Dermatologic Clinic, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
2
2 Anatomic Pathology, University of Rome Tor Vergata, Rome, Italy.
3
3 Department of Surgical Sciences, University of Tirana, Nostra Signora del Buon Consiglio, Tirana, Albania.

Abstract

OBJECTIVE:

Skin aging is a complex process influenced by several factors that cause DNA damage and alter the extracellular matrix. The anti-inflammatory drug piroxicam can counteract photocarcinogenesis and photoaging by blocking cyclooxygenases-1 and 2, matrix metalloproteinases, and ornithine decarboxylase, and inducing apoptosis.

METHODS:

We conducted an open observational study in 50 adults with moderate to severe signs of photoaging treated with a new local formulation of piroxicam 0.8% plus sunscreen for 16 weeks. Photoaging was assessed using a validated dermoscopic photoaging scale. Each patient's own perception of their skin quality was assessed using a graphic scale.

RESULTS:

The new formulation demonstrated a reliable effect on photoaging after 16 weeks, based on improved median dermoscopic photoaging and skin-quality scores. No patients experienced any adverse effects.

CONCLUSIONS:

To the best of our knowledge, this study provides the first evidence for the safe and effective use of a local piroxicam formulation for the treatment of moderate to severe photoaging.

KEYWORDS:

Photoaging; dermoscopy; elderly; non-steroidal anti-inflammatory drug; piroxicam; topical administration

PMID:
31167591
DOI:
10.1177/0300060519850392

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