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Nutrients. 2019 Jun 4;11(6). pii: E1271. doi: 10.3390/nu11061271.

Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols.

Author information

1
Villa dei Gerani Hospital, 89900 Vibo Valencia, Italy. scapomolla@gmail.com.
2
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy. janda@unicz.it.
3
Interregional Research Center for Food Safety and Health, 88100 Catanzaro, Italy. janda@unicz.it.
4
Interregional Research Center for Food Safety and Health, 88100 Catanzaro, Italy. mparafati@unicz.it.
5
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy. t.sawicki@pan.olsztyn.pl.
6
Interregional Research Center for Food Safety and Health, 88100 Catanzaro, Italy. t.sawicki@pan.olsztyn.pl.
7
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy. rocco.mollace@gmail.com.
8
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, 10-748 Olsztyn, Poland. rocco.mollace@gmail.com.
9
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy. sragusa@unicz.it.
10
Interregional Research Center for Food Safety and Health, 88100 Catanzaro, Italy. sragusa@unicz.it.
11
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy. sara.paone06@gmail.com.
12
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy. mollace@unicz.it.
13
Interregional Research Center for Food Safety and Health, 88100 Catanzaro, Italy. mollace@unicz.it.
14
San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pisana, 00163 Rome, Italy. mollace@unicz.it.

Abstract

: Bergamot flavonoids counteract dyslipidemia and hyperglycemia but fail to induce a significant weight loss. Here, we evaluated the efficacy of bergamot polyphenol extract complex (BPE-C), a novel bergamot juice-derived formulation enriched with flavonoids and pectins, on several metabolic syndrome parameters. Obese patients with atherogenic index of plasma (AIP) over 0.34 and mild hyperglycemia were recruited to a double-blind randomized trial comparing two doses of BPE-C (650 and 1300 mg daily) with placebo. Fifty-two subjects met the inclusion criteria and were assigned to three experimental groups. Fifteen subjects per group completed 90 days-trial. BPE-C reduced significantly fasting glucose by 18.1%, triglycerides by 32% and cholesterol parameters by up to 41.4%, leading to a powerful reduction of AIP (below 0.2) in the high dose group. The homeostasis model assessment of insulin resistance (HOMA-IR) and insulin levels were also reduced. Moreover, BPE-C decreased body weight by 14.8% and body mass index by 15.9% in BPE-C high group. This correlated with a significant reduction of circulating hormones balancing caloric intake, including leptin, ghrelin and upregulation of adiponectin. All effects showed a dose-dependent tendency. This study suggests that food supplements, containing full spectrum of bergamot juice components, such as BPE-C efficiently induce a combination of weight loss and insulin sensitivity effects together with a robust reduction of atherosclerosis risk.

KEYWORDS:

atherosclerosis; bergamot polyphenol fraction (BPF); body mass index; cardiovascular risk factors; clinical trial; insulin resistance; metabolic syndrome; obesity

PMID:
31167512
DOI:
10.3390/nu11061271
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