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Structure. 2019 Jun 4;27(6):879-881. doi: 10.1016/j.str.2019.05.006.

Lou Gehrig's Disease (ALS): UBQLN2 Mutations Strike Out of Phase.

Author information

1
The Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
2
The Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: monteiro@som.umaryland.edu.

Abstract

In this issue of Structure, Dao et al. (2019) report that ALS-linked mutations in the Pxx domain of Ubiquilin 2 (UBQLN2) differentially influence the protein's phase separation abilities. The affect is by reducing the temperature and UBQLN2 concentration necessary for liquid-liquid phase separation droplet formation and by modulating UBQLN2 oligomerization.

PMID:
31167121
DOI:
10.1016/j.str.2019.05.006

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