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Nanomedicine (Lond). 2019 Jun;14(11):1471-1491. doi: 10.2217/nnm-2018-0348. Epub 2019 Jun 5.

Nanomedicine as a future therapeutic approach for Hepatitis C virus.

Author information

1
Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, Medical Sciences Building, University of Cincinnati, Cincinnati, OH 45267, USA.
2
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
3
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
4
Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy, Mutah University, Karak, Jordan.
5
Central Research Facilities, Sri Ramachandra institute of higher education & research, Sri Ramachandra University, Chennai, India.
6
Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut, 71526, Egypt.
7
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.

Abstract

Hepatitis C virus (HCV) is not easily cleared from the human body and in most cases turned into chronic infection. This chronicity is a major cause of liver damage, cirrhosis and hepatocellular carcinoma. Therefore, immediate detection and treatment of HCV guarantees eradication of the virus and prevention of chronicity complications. Since discovery of HCV in 1989, several emerging treatments were developed such as polyethylene glycol(PEG)-ylated interferon/ribavirin, direct acting antivirals and host targeting antivirals. Despite the progress in anti-HCV therapy, there is still a pressing need of new approaches for affordable and effective drug delivery systems using nanomedicine. In this review, the contribution of nanoparticles as a promising delivery system for HCV immunizing, diagnostic and therapeutic agents are discussed.

KEYWORDS:

anti-HCV; anti-hepatitis C virus; antiviral drugs; hepatitis C virus; nanomedicine; nanoparticles

PMID:
31166139
DOI:
10.2217/nnm-2018-0348

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