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Ginekol Pol. 2019;90(5):262-269. doi: 10.5603/GP.2019.0049.

Is polycystic ovarian syndrome and insulin resistance associated with abnormal uterine bleeding in adolescents?

Author information

1
Woman's Health Chair, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland. urbanskaeve@interia.pl.
2
Department and Clinic of Gynaecology and Obstetrics, Wroclaw Medical University, Wroclaw, Poland.
3
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine, Medical University of Silesia, Katowice, Poland.
4
Woman's Health Chair, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
5
Department of the Internal Disease, Dermatology and Allergy, European Center of Diagnosis and Treatment of Urticaria, School of Medicine in Zabrze, Medical University of Silesia, Katowice, Poland.

Abstract

OBJECTIVES:

The aim of the study was to determine if adolescents with juvenile bleeding had polycystic ovarian syndrome (PCOS) and insulin resistance.

MATERIAL AND METHODS:

The study was conducted in a group of 43 females aged 12-18 years, diagnosed with juvenile menorrhagia, and 37 healthy female adolescents aged 12-18 years. The study was conducted during the early follicular phase of the menstrual cycle. Menstrual cycle disturbances, acne and hirsutism were recorded. Ultrasound scan determining the condition of the ovaries was conducted. Laboratory tests of the glucose level, cholesterol, LDL and HDL cholesterol and triglycerides fraction, DHEAS, FSH, LH, insulin, SHGB, total testosterone, androstenedione, and free testosterone have been established.

RESULTS:

The occurrence of regular menstrual cycles (30.23%, p = 0.006) was significantly lower in the juvenile bleeding group. Also, secondary amenorrhea was significantly more likely to be recognized in this group of females (p = 0.03). The concentration of FSH was considerably lower (p = 0.0002) in the group of adolescents with AUB.

CONCLUSIONS:

Adolescents with abnormal uterine bleeding (AUB) are often diagnosed with secondary amenorrhea, and PCOS. The group with a diagnosis of juvenile bleeding was also diagnosed with higher rates of insulin resistance.

KEYWORDS:

abnormal uterine bleeding; hyperandrogenism; insulin resistance; polycystic ovarian syndrome

PMID:
31165465
DOI:
10.5603/GP.2019.0049
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