Format

Send to

Choose Destination
Curr Biol. 2019 Jun 3;29(11):R422-R424. doi: 10.1016/j.cub.2019.04.052.

Gene Regulation: Analog to Digital Conversion of Transcription Factor Gradients.

Author information

1
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Electronic address: Dimitrios.papadopoulos@igmm.ed.ac.uk.
2
Max-Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address: tomancak@mpi-cbg.de.

Abstract

Transcription factor gradients trigger differential transcriptional responses based on concentration. But how, in some cases, do target genes maintain uniform transcription across portions of the gradient? Lessons from Drosophila demonstrate that organization of transcription into 'hubs' can lead to local increases in transcription factor concentration.

PMID:
31163148
DOI:
10.1016/j.cub.2019.04.052

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center