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Liver Int. 2019 Jun 4. doi: 10.1111/liv.14164. [Epub ahead of print]

Association between nut consumption and non-alcoholic fatty liver disease in adults.

Author information

1
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
2
Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.
3
Tianjin Institute of Environmental & Operational Medicine, Tianjin, China.
4
The Third Central Clinical College of Tianjin Medical University, Tianjin, China.
5
Department of Gastroenterology, Tianjin Third Central Hospital, Tianjin, China.

Abstract

BACKGROUND & AIMS:

Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population.

METHODS:

A total of 23 915 participants from Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD.

RESULTS:

After adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2-3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers.

CONCLUSIONS:

Higher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.

KEYWORDS:

NAFLD; adults; non-alcoholic fatty liver disease; nuts

PMID:
31162803
DOI:
10.1111/liv.14164

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