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Curr Med Chem. 2019 Jun 3. doi: 10.2174/0929867325666190603110907. [Epub ahead of print]

Toll-like receptors as potential therapeutic targets in kidney diseases.

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Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041. China.


Toll-like receptors (TLRs) are members of pattern recognition receptors and serve pivotal role in host immunity. TLRs response to pathogen-associated molecular patterns encoded by pathogens or damage-associated molecular patterns released by dying cells, initiating an inflammatory cascade, where both beneficial and detrimental effects can be exerted. Accumulated evidence has revealed TLRs tightly associate with various kidney diseases but their roles are still not well understood. This review updated evidence on roles of TLRs in the pathogenesis of kidney diseases including urinary tract infection, glomerulonephritis, acute kidney injury, transplant allograft dysfunction and chronic kidney diseases.


Toll-like receptors; innate immunity; kidney diseases,therapy

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