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Acad Emerg Med. 2019 Jun 4. doi: 10.1111/acem.13811. [Epub ahead of print]

Underdosing of Benzodiazepines in Patients with Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial.

Author information

1
Department of Experimental and Clinical Pharmacology, College of Pharmacy and Center for Orphan Drug Research, University of Minnesota, Minneapolis, MN.
2
The Department of Public Health Science, Medical University of South Caroline, Charleston, SC.
3
The Department of Emergency Medicine, University of Michigan, Ann Arbor, MI.
4
The Division of Emergency Medicine, Children's National Health System and the Department of Pediatrics and Emergency Medicine, School of Medicine and Health Sciences, George Washington University Washington, DC.
5
The Department of Neurology, Brain Institute, University of Virginia, Charlottesville, VA.
6
The Department of Neuroscience, Brain Institute, University of Virginia, Charlottesville, VA.
7
St. George's University of London and St. George's University Hospitals NHS Foundation Trust, London, UK.
8
Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
9
The Department of Neurology, University of California, San Francisco, CA.
10
National Institute of Neurological, Disorders and Stroke, National Institutes of Health, Bethesda, MD.
11
Feinberg School of Medicine, Northwestern University and Rush Medical College, Chicago, IL.

Abstract

Benzodiazepines, including diazepam (DZP), lorazepam (LZP), and midazolam (MDZ), are considered the initial drugs of choice for status epilepticus (SE) treatment. A number of trials have demonstrated their safety and efficacy; however, the failure rate ranges from 10-55%.1,2 This may be attributable, in part, to sub-optimal benzodiazepine dosing and timing of administration. The Neurocritical Care Society (NCS) and American Epilepsy Society (AES) have published evidence-based guidelines for benzodiazepine use in SE that specify drugs, doses, and routes of administration. This article is protected by copyright. All rights reserved.

KEYWORDS:

Benzodiazepines; Dose; Emergency Medicine; Status Epilepticus

PMID:
31161706
DOI:
10.1111/acem.13811

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