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J Res Med Sci. 2019 May 22;24:46. doi: 10.4103/jrms.JRMS_1062_18. eCollection 2019.

Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures.

Author information

1
Department of Orthopedics, AJA University of Medical Sciences, Tehran, Iran.
2
Department of Pharmacology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background:

The high socioeconomic impact of osteoporosis and osteoporotic fracture is due to their high mortality, morbidity, and disease-related costs. Nowadays, bone mineral density (BMD) is a comparatively expensive way to diagnose and follow up patients with osteoporosis. Transforming growth factor-β3 (TGF-β3) is a protein categorized into cytokines. Some previous in vitro studies showed TGF-β3 effects on osteocytes and bone formation. Therefore, we conducted this study to find if there is any significant relationship between TGF-β3 and BMD results.

Materials and Methods:

This was an analytical cross-sectional study conducted in 2017. We included individuals who had been referred from their physicians to undergo BMD dual-energy X-ray absorptiometry. Blood samples were taken from 150 participants for measuring TGF-β3 with ELISA method.

Results:

The mean ± standard deviation of TGF-β3 serum level was 79 ± 30.8 pg/ml (minimum 41 pg/ml and maximum 210 pg/ml). There was a statistically significant and direct proportional relationship between TGF-β3 and T-score as a marker for the diagnosis and follow-up of osteoporosis and osteoporotic fracture (P = 0.001) (Pearson's correlation = +0.95).

Conclusion:

There was a significant relationship between TGF-β3 serum level and BMD. TGF-β3 serum level may be used as a marker for the diagnosis and follow-up of osteoporosis and osteoporotic fracture.

KEYWORDS:

Osteoporosis; osteoporotic fractures; transforming growth factor-β3

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