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Trends Immunol. 2019 May 31. pii: S1471-4906(19)30101-2. doi: 10.1016/j.it.2019.04.012. [Epub ahead of print]

Neutrophil Diversity in Health and Disease.

Author information

1
Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany.
2
Institute of Pulmonary Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
3
Faculty of Dentistry, University of Toronto, and Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
4
Department of Medicine, Section of General Pathology, School of Medicine, University of Verona, Verona, Italy. Electronic address: patrizia.scapini@univr.it.

Abstract

New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.

KEYWORDS:

immune regulation; neutrophils; subpopulations

PMID:
31160207
DOI:
10.1016/j.it.2019.04.012

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