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Fitoterapia. 2019 Sep;137:104189. doi: 10.1016/j.fitote.2019.104189. Epub 2019 May 31.

Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production.

Author information

1
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2
Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
3
Institute of TCM International Standardization of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
4
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
5
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: ymlius@163.com.
6
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: wr@shutcm.edu.cn.

Abstract

Seventeen lignans (1-17) were obtained from the roots of Isatis indigotica (I. indigotica). Among them, isatindigosesquilignans A-C (1-3) were deduced as three undescribed sesquilignans, which possess unusual carbon skeleton of aryltetralin unit connected with a C6-C3 moiety via a five-membered ring of C-3-C-8″-C-7″-O-C-4. Isatindigosesquilignans B and C were determined as the first examples of its glycosides from a natural source and a plausible biosynthetic pathway was proposed. Moreover, all of the isolated lignans were assayed regarding their inhibitory effects on nitric oxide (NO) production in RAW 264.7 cells and compounds 1, 2 and 7 showed inhibitory effects with IC50 values ranging from 19.46 μM to 64.82 μM.

KEYWORDS:

Anti-inflammatory activity; Isatis indigotica; Lignans; Nitric oxide production; Structure determination

PMID:
31158429
DOI:
10.1016/j.fitote.2019.104189
[Indexed for MEDLINE]

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