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Stud Health Technol Inform. 2019;261:274-279.

Brain-on-a-Chip: A Human 3D Model for Clinical Application.

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Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genova, Genova, Italy.
Clinical Neurophysiology, University of Twente, Enschede, The Netherlands.


The main goal of this research is to design, develop and implement an efficient protocol to generate 3D neural cultures derived from human induced Pluripotent Stem Cells (hiPSCs) coupled to Micro Electrode Arrays (MEA) in order to obtain an engineered and controlled brain-on-a-chip model. The use of patient specific iPSCs may offer novel insights into the pathophysiology of a large variety of disorders, including numerous neurodevelopmental and late-onset neurodegenerative conditions. With these in vitro patient specific models, we may have the possibility to test drugs and find ad hoc therapies in the direction of precision medicine.


3D brain model; Brian-on-a-chip; human induced pluripotent stem cells electrophysiology; micro electrodes array


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