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Cell. 1987 Oct 9;51(1):113-9.

A new class of yeast transcriptional activators.

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Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.


We describe yeast transcriptional activators encoded by E. coli genomic DNA fragments fused to the coding sequence of the DNA-binding portion of GAL4. All of the new activating sequences that we have analyzed, like those of GAL4 and GCN4, are acidic; most of these sequences show no obvious sequence homology when compared with the identified activating regions of GAL4 and GCN4 or among themselves. We also describe a fusion protein that contains no yeast protein sequence but activates transcription in yeast.

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