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Cancer Gene Ther. 2019 Jun 3. doi: 10.1038/s41417-019-0107-9. [Epub ahead of print]

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma.

Xiao W1,2,3,4, Wang X1,2,3,4, Wang T1,2,3,4, Xing J5,6,7,8.

Author information

1
Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
2
Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
3
The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
4
The First Clinical College of Fujian Medical University, Xiamen, Fujian, China.
5
Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. xmfhxjc@163.com.
6
Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. xmfhxjc@163.com.
7
The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China. xmfhxjc@163.com.
8
The First Clinical College of Fujian Medical University, Xiamen, Fujian, China. xmfhxjc@163.com.

Abstract

Clear cell renal cell carcinoma (ccRCC) is the highest mortality, invasion, and metastasis subtype of renal cell carcinoma. Bone morphogenetic protein (BMP) family has recently emerged as a group of cancer-related proteins in multiple pathogenesis of cancers. Currently, little is known about the prediction role of BMPs in ccRCC. Therefore, we screened The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database for ccRCC patients with complete clinical information and BMP family expression data. Multivariate analysis showed that high expression of BMP1 was associated with shorter overall survival (OS) (Pā€‰=ā€‰0.001), and shorter disease-free survival (DFS) (Pā€‰=ā€‰0.018). Gene set enrichment analysis (GSEA) showed BMP1 was associated with epithelial-mesenchymal transition (EMT), G2M checkpoint, angiogenesis, hypoxia pathway, and Kirsten rat sarcoma viral oncogene (KRAS) signaling. Knockdown BMP1 suppressed malignancy of ccRCC in vitro and in vivo. Our results indicated that high expressions of BMP1 were poor prognostic factors and gene therapy could be an effective treatment for ccRCC.

PMID:
31155610
DOI:
10.1038/s41417-019-0107-9

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