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J Clin Neurosci. 2019 Aug;66:51-55. doi: 10.1016/j.jocn.2019.05.025. Epub 2019 May 30.

Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China.

Author information

1
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
2
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
3
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Centre for Neuromuscular and Neurological Disorders, Perron Institute, University of Western Australia, Perth, Australia.
4
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: qiuwei120@vip.163.com.
5
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: alexlau@cuhk.edu.hk.

Abstract

The data for oligoclonal IgG bands (OCB) in cerebrospinal fluid and the association with clinical profiles of Chinese patients with multiple sclerosis (MS) is lacking. We aimed to investigate the positive OCB incidence, as well as the clinical and magnetic resonance imaging (MRI) features associated with positive OCB in MS patients in South China. Consecutive MS patients were recruited from two centers, located in Guangzhou city and Hong Kong in South China. MS was re-diagnosed by McDonald criteria 2017. OCB was tested using isoelectric focusing method. The difference in the clinical and MRI features between OCB-positive and OCB-negative MS patients was evaluated. Among 184 MS patients analyzed (102 from Guangzhou and 82 from Hong Kong), 110 (59.8%) patients were OCB-positive. Except for onset age (P = 0.019), there was no significant difference between MS patients with or without OCB in relation to the course of disease, symptoms of first attack, lesion distribution on MRI, relapse rates, or disability progression. Our results demonstrate no significant clinical differences between the OCB positive and negative MS patients in this MS cohort. Larger cohort in Chinese patients with MS is warranted.

KEYWORDS:

Chinese; Magnetic resonance imaging; Multiple sclerosis; Oligoclonal IgG bands

PMID:
31155343
DOI:
10.1016/j.jocn.2019.05.025
[Indexed for MEDLINE]

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