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Trends Mol Med. 2019 May 30. pii: S1471-4914(19)30107-8. doi: 10.1016/j.molmed.2019.05.005. [Epub ahead of print]

A Single Human Neuron Approach to Synapse Function.

Author information

1
Institute of Neurophysiology, Charité - Universitätsmedizin, 10117, Berlin, Germany; NeuroCure Cluster of Excellence, Charité - Universitätsmedizin, 10117, Berlin, Germany.
2
Institute of Neurophysiology, Charité - Universitätsmedizin, 10117, Berlin, Germany; NeuroCure Cluster of Excellence, Charité - Universitätsmedizin, 10117, Berlin, Germany. Electronic address: christian.rosenmund@charite.de.

Abstract

To understand human neuronal function, it is crucial to obtain knowledge of how human synapses operate. New approaches are necessary to define the unique properties of human synapses. Recently, new culturing approaches have been developed to obtain cultures of single human neurons for the first time (Rhee et al., Cell Rep. 2019, Meijer et al., Cell Rep. 2019, and Fenske et al., Sci. Rep. 2019).

KEYWORDS:

human neuron; iPSC; single-cell model; synaptic transmission

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