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Curr Opin Cell Biol. 2019 Aug;59:140-146. doi: 10.1016/j.ceb.2019.04.010. Epub 2019 May 30.

Transport carrier tethering - how vesicles are captured by organelles.

Author information

1
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: ag@mrc-lmb.cam.ac.uk.
2
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: sean@mrc-lmb.cam.ac.uk.

Abstract

All cells contain numerous membrane-bound organelles that carry out specific functions. These compartments do not, however, act in isolation. Some are in direct contact via membrane contact sites, while others exchange material via specific vesicles or tubular carriers laden with cargo. The term tethering in the context of this review is used to describe the primary recognition and docking of transport carriers with acceptor organelles that occurs before SNARE engagement and membrane fusion. However, it is important to note that other tethering events occur, for example, between organelles in direct contact, which do not lead to fusion.

PMID:
31154044
DOI:
10.1016/j.ceb.2019.04.010

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