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Aust Dent J. 2019 Sep;64(3):256-262. doi: 10.1111/adj.12705. Epub 2019 Jun 21.

Adjunctive photodynamic therapy improves the outcomes of peri-implantitis: a randomized controlled trial.

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Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.



Photodynamic therapy (PDT) can be used for the management of peri-implantitis. This study aimed to explore the efficacy and safety of PDT for peri-implantitis in Chinese Han patients.


This was a single-centre, open-label, randomized controlled trial of participants with peri-implantitis treated at the Beijing Chao-Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/mL; 3 min) and a 635-nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm2 ). The primary outcome was the decline in periodontal probing depth (PD) at 6 months. The secondary outcomes were peri-implant plaque index (PLI), sulcular bleeding index (SBI), and clinical attachment loss (CAL).


PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3- and 6-month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better (P < 0.05 vs. controls).


PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri-implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.


Mechanical debridement; peri-implantitis; photodynamic therapy; randomized controlled trial


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