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Curr Opin Chem Biol. 2019 Oct;52:31-38. doi: 10.1016/j.cbpa.2019.04.020. Epub 2019 May 28.

Engineering cell-cell communication networks: programming multicellular behaviors.

Author information

1
Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, and Center for Systems and Synthetic Biology, University of California San Francisco, San Francisco, CA 94158, USA.
2
Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, and Center for Systems and Synthetic Biology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: wendell.lim@ucsf.edu.

Abstract

Cell-cell communication governs the biological behaviors of multicellular populations such as developmental and immunological systems. Thanks to intense genetic analytical studies, the molecular components of cell-cell communication pathways have been well identified. We also have been developing synthetic biology tools to control cellular sensing and response systems that enable engineering of new cell-cell communication with design-based regulatory features. Recently, using these molecular backgrounds, synthetic cellular networks have been built and tested to understand the basic principles of multicellular biological behaviors. These approaches will provide new capabilities to control and program desired biological behaviors with engineered cell-cell communication to apply them toward cell-based therapeutics.

PMID:
31150899
DOI:
10.1016/j.cbpa.2019.04.020

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