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Neurobiol Dis. 2019 Oct;130:104485. doi: 10.1016/j.nbd.2019.104485. Epub 2019 May 28.

Ionic and synaptic mechanisms of seizure generation and epileptogenesis.

Author information

1
Neurosciences Graduate Program, University of California, San Diego, CA 92093, United States of America; Department of Medicine, University of California, San Diego, CA 92093, United States of America.
2
Department of Medicine, University of California, San Diego, CA 92093, United States of America.
3
Centre de recherche de l'Institut universitaire en santé mentale de Québec (CRIUSMQ), 2601 de la Canardière, Québec, QC, Canada; Department of Psychiatry and Neuroscience, Université Laval, Québec, QC, Canada.
4
Neurosciences Graduate Program, University of California, San Diego, CA 92093, United States of America; Department of Medicine, University of California, San Diego, CA 92093, United States of America. Electronic address: mbazhenov@ucsd.edu.

Abstract

The biophysical mechanisms underlying epileptogenesis and the generation of seizures remain to be better understood. Among many factors triggering epileptogenesis are traumatic brain injury breaking normal synaptic homeostasis and genetic mutations disrupting ionic concentration homeostasis. Impairments in these mechanisms, as seen in various brain diseases, may push the brain network to a pathological state characterized by increased susceptibility to unprovoked seizures. Here, we review recent computational studies exploring the roles of ionic concentration dynamics in the generation, maintenance, and termination of seizures. We further discuss how ionic and synaptic homeostatic mechanisms may give rise to conditions which prime brain networks to exhibit recurrent spontaneous seizures and epilepsy.

KEYWORDS:

Computational model; Epileptic seizures; Homeostatic synaptic plasticity; Ion concentration dynamics

PMID:
31150792
PMCID:
PMC6689444
[Available on 2020-10-01]
DOI:
10.1016/j.nbd.2019.104485

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