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PLoS One. 2019 May 31;14(5):e0217609. doi: 10.1371/journal.pone.0217609. eCollection 2019.

Exploring the effects of COLOSTRONONI on the mammalian gut microbiota composition.

Author information

1
Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
2
GenProbio srl Parma, Parma, Italy.
3
Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
4
Microbiome Research Hub, University of Parma, Parma, Italy.

Abstract

COLOSTRONONI is a dietary supplement consisting of bovine colostrum and Morinda citrifolia fruit (Noni). In this study, we tested the capability of COLOSTRONONI to influence gut microbiota composition using an in vivo evaluation in rats. Furthermore, we analyzed the effect of COLOSTRONONI on the systemic inflammatory responses as well as on the gut permeability of the animals. Altogether, our analyses supported the concept of COLOSTRONONI as a natural food supplement that doesn't affect (neither negatively nor positively) gut microbiota homeostasis in healthy conditions. Moreover, COLOSTRONONI highlighted a lower effect in the expression of genes coding for IL-10, Il-12 and TNF-α response allowing us to hypothesize an immunomodulatory activity of this dietary supplement.

PMID:
31150516
PMCID:
PMC6544264
DOI:
10.1371/journal.pone.0217609
[Indexed for MEDLINE]
Free PMC Article

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