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Acta Endocrinol (Buchar). 2016 Apr-Jun;12(2):130-136. doi: 10.4183/aeb.2016.130.

EFFECTS OF EXERCISE ON MIR-29 AND IGF-1 EXPRESSION AND LIPID PROFILE IN THE HEART OF OVARIECTOMIZED RAT.

Author information

1
Tabriz University of Medical Sciences, Department of Physiology, Islamic Republic of Iran.
2
Tabriz University of Medical Sciences, Department of Histology & Embryology, Islamic Republic of Iran.
3
Tabriz University of Medical Sciences, Neuroscience Research Center, Islamic Republic of Iran.
4
Islamic Azad University, Tabriz Branch, Department of Physiology, Tabriz, Islamic Republic of Iran.
5
Guilan University of Medical Sciences, Poursina Hospital, School of Medicine, Department of Neurosurgery, Rasht, Islamic Republic of Iran.
6
Tabriz University of Medical Sciences, Drug Applied Research Center, Islamic Republic of Iran.

Abstract

Introduction:

Menopause increases the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of swimming training on cardiac histology and expression of miR-29 and IGF-1 in the ovariectomized rats.

Materials and methods:

Thirty female Wistar rats were divided into sham and ovariectomized groups: sedentary control (OVX) and trained with 8 weeks exercise (OVX.E). On 57th day, blood was collected and used for lipid profile measurement. In addition, heart tissue was analyzed by reverse transcription-polymerase chain reaction for IGF-1 mRNA and miR-29, and studied for histopathological changes.

Results:

Ovariectomy significantly decreased miR-29 and IGF-1 expression in the heart compared to sham animals group (p<0.05). Exercise training increased miR-29 and IGF-1 expression in the trained rats and improved histology and lipid profile compared with OVX group (p<0.05).

Conclusion:

Estrogen deficiency could lead to cardiac fibrosis through deregulation miR-29 and IGF-1 expression. The findings of the current study suggests a protective effect of exercise on heart against fibrotic changes in ovariectomized rats and support a potential preventive value of exercise in improving cardiac function after menopause.

KEYWORDS:

IGF-1; Ovariectomy; heart; miR-29; swimming training

Conflict of interest statement

The authors report no conflict of interest.

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