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Obes Surg. 2019 May 30. doi: 10.1007/s11695-019-03914-4. [Epub ahead of print]

Alterations in Fat Mass and Bone Mineral Density Are Associated with Decreased Lipocalin-2 After Laparoscopic Sleeve Gastrectomy in Obese Chinese Women.

Wen X1,2,3, Zhu B1,2,3, Zhang Y4, Mei F1,2,3, Cheng X1,2,3, Qian C1,2,3, Yang P1,2,3, Lu L5, Zhou D5, Gao J1,2,3, Bu L6,7,8, Qu S1,2,3.

Author information

1
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai, 200072, China.
2
National Metabolic Management Center, Shanghai, 200072, China.
3
Thyroid Research Center of Shanghai, Shanghai, 200072, China.
4
Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
5
Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
6
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai, 200072, China. geyingjun@hotmail.com.
7
National Metabolic Management Center, Shanghai, 200072, China. geyingjun@hotmail.com.
8
Thyroid Research Center of Shanghai, Shanghai, 200072, China. geyingjun@hotmail.com.

Abstract

OBJECTIVE:

Lipocalin-2 (LCN2) plays an important role in the regulation of the obesity and obesity-related dysmetabolic state. This study aimed to analyze serum LCN2 level in Chinese women with obesity before and after laparoscopic sleeve gastrectomy (LSG) and determine the association between alteration in fat mass and bone mineral density (BMD) and LCN2 level.

METHODS:

Fifty-two women (38 patients with obesity and 14 with normal body mass index (BMI)) were enrolled in this study. All patients with obesity underwent LSG. BMDs of the arm, leg, thoracic and lumbar spine, and pelvis were measured by dual-energy X-ray absorptiometry. Body fat mass and distribution were measured by dual-energy X-ray absorptiometry, and routine anthropometric/laboratory biochemical parameters at baseline and 3 and 12 months after LSG were recorded. Serum LCN2 levels were measured using an enzyme-linked immunosorbent assay.

RESULTS:

Serum LCN2 level was significantly higher in women with obesity than in the controls with normal BMI (102.70 ± 27.19 vs. 80.66 ± 19.55 ng/mL, P = 0.009). LCN2 level was decreased at 3 and 12 months after LSG (86.73 ± 26.79 ng/mL, P = 0.171, and 64.79 ± 28.39 ng/mL, P < 0.001, respectively). LSG led to marked body fat mass and slight BMD decrease. Decreased LCN2 level was significantly correlated with alterations in left and right leg BMDs and trunk fat mass at 12 months after LSG.

CONCLUSIONS:

Obesity was associated with up-regulated serum LCN2 level. Decreased LCN2 level was positively correlated with changes in BMD and fat mass at 12 months after LSG in Chinese women.

KEYWORDS:

Body fat distribution; Bone mineral density; Laparoscopic sleeve gastrectomy; Lipocalin-2; Obesity

PMID:
31147821
DOI:
10.1007/s11695-019-03914-4

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