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Genome Biol. 2019 May 30;20(1):111. doi: 10.1186/s13059-019-1719-y.

Genome-wide analysis of DNA replication timing in single cells: Yes! We're all individuals.

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Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.


Recent studies have accomplished the extraordinary feat of measuring the exact status of DNA replication in individual cells. We outline how these studies have revealed surprising uniformity in how cells replicate their DNA, and consider the implications of this remarkable technological advance.

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