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Mar Drugs. 2019 May 29;17(6). pii: E315. doi: 10.3390/md17060315.

In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway.

Feng CW1,2, Chen NF3,4, Wen ZH5,6, Yang WY7, Kuo HM8,9, Sung PJ10,11,12, Su JH13,14, Cheng SY15,16,17, Chen WF18,19.

Author information

1
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. qscjuejuejue@gmail.com.
2
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. qscjuejuejue@gmail.com.
3
Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan. chen06688@gmail.com.
4
Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan. chen06688@gmail.com.
5
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
6
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
7
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. s8222889@gmail.com.
8
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. hsiaomeikuo@gmail.com.
9
Center for Neuroscience, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. hsiaomeikuo@gmail.com.
10
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
11
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
12
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
13
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
14
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
15
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. joygetit@gmail.com.
16
Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Nankang, Taipei 115, Taiwan. joygetit@gmail.com.
17
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. joygetit@gmail.com.
18
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. ma4949@cgmh.org.tw.
19
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. ma4949@cgmh.org.tw.

Abstract

Pharmaceutical agents for halting the progression of Parkinson's disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed.

KEYWORDS:

HO-1; Nrf2; Parkinson’s disease; apoptosis; oxidative stress; sponge-derived compound

PMID:
31146323
DOI:
10.3390/md17060315
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