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Curr Opin Psychiatry. 2019 Jun 19. doi: 10.1097/YCO.0000000000000533. [Epub ahead of print]

Repetitive transcranial magnetic stimulation treatment for depressive disorders: current knowledge and future directions.

Author information

1
Department of Psychiatry and Medical Psychology, Ghent University.
2
Ghent Experimental Psychiatry (GHEP) Lab.
3
Department of Psychiatry, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZBrussel), Laarbeeklaan, Brussels, Belgium.
4
Max-Planck Institute of Psychiatry, Munich, Germany.
5
Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
6
Research Institute Brainclinics, Nijmegen, The Netherlands.
7
Department Experimental Psychology, Utrecht University, Utrecht, The Netherlands.
8
Departments of Internal Medicine and Psychiatry, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
9
Psychiatric hospital 'Sveti Ivan'.
10
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
11
Faculty of Psychology and Educational Sciences, Center for Research in Neuropsychology and Cognitive Behavioral Intervention, University of Coimbra, Portugal.
12
Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
13
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
14
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, PSY-R2 Team, University Claude Bernard Lyon1, F-69000, France.
15
Private Practice, 7, place de la Fusterie, 1204 Geneva, Switzerland.
16
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
17
Department of Experimental Clinical and Health Psychology.
18
Department of Clinical Psychiatry, CHU de Besançon, CIC-1431 INSERM, CHU de Besançon, EA481 Neurosciences, University Bourgogne Franche-Comte, FondaMental Foundation, 94000 Creteil, France.

Abstract

PURPOSE OF REVIEW:

After three decades of clinical research on repetitive transcranial magnetic stimulation (rTMS), major depressive disorder (MDD) has proven to be the primary field of application. MDD poses a major challenge for health systems worldwide, emphasizing the need for improving clinical efficacy of existing rTMS applications and promoting the development of novel evidence-based rTMS treatment approaches.

RECENT FINDINGS:

Several promising new avenues have been proposed: novel stimulation patterns, targets, and coils; combinatory treatments and maintenance; and personalization and stratification of rTMS parameters, and treatment of subpopulations.

SUMMARY:

This opinion review summarizes current knowledge in the field and addresses the future direction of rTMS treatment in MDD, facilitating the establishment of this clinical intervention method as a standard treatment option and continuing to improve response and remission rates, and take the necessary steps to personalize rTMS-based treatment approaches.

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