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J Cachexia Sarcopenia Muscle. 2019 May 29. doi: 10.1002/jcsm.12442. [Epub ahead of print]

Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial.

Author information

1
Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, University of Navarra (UNAV), Pamplona, Spain.
2
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
3
IdiSNA (Instituto de Investigación Sanitaria de Navarra), Pamplona, Spain.
4
Instituto de Investigación Sanitaria Illes Balears (IdISBa), University Hospital Son Espases, Palma de Mallorca, Spain.
5
Department of Biochemistry and Biotechnology, Human Nutrition Unit, IISPV, Rovira i Virgili University, Hospital Universitari Sant Joan de Reus, Reus, Spain.
6
Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
7
Department of Endocrinology, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
8
CIBER Diabetes y enfermedades metabólicas (CIBERdem), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
9
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
10
Atención Primaria, Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
11
Institut Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
12
Vascular Risk Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
13
Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Vitoria, Spain.
14
Instituto de Biomedicina (IBIOMED), University of León, León, Spain.
15
Division of Preventive Medicine, University of León, León, Spain.
16
CIBER Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
17
Madrid Institute for Advanced Studies (IMDEA), Food Institute, Madrid, Spain.
18
Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Endocrinology and Diabetes Unit, Department de Medicina, Hospital del Mar Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.

Abstract

BACKGROUND:

Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to 'sarcopenic obesity'. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity.

METHODS:

A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2 ; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables.

RESULTS:

Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-to-lymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance.

CONCLUSIONS:

Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age-related sarcopenia.

KEYWORDS:

Leucocyte count; Mediterranean diet score; Physical activity; Sarcopenic index; Systemic inflammation; Visceral fat

PMID:
31144432
DOI:
10.1002/jcsm.12442
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