Interaction of tumor-associated macrophages and cancer chemotherapy

Irina Larionova; Nadezhda Cherdyntseva; Tengfei Liu; Marina Patysheva; Militsa Rakina; Julia Kzhyshkowska

doi:10.1080/2162402X.2019.1596004

Interaction of tumor-associated macrophages and cancer chemotherapy

Oncoimmunology. 2019 Apr 13;8(7):1596004. doi: 10.1080/2162402X.2019.1596004. eCollection 2019.

Authors

Irina Larionova^{1

2}, Nadezhda Cherdyntseva^{1

2}, Tengfei Liu³, Marina Patysheva², Militsa Rakina¹, Julia Kzhyshkowska^{1

3

4}

Affiliations

¹ Laboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, Tomsk, Russia.
² laboratory of molecular oncology and immunology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
³ Department of Innate Immunity and Tolerance, University of Heidelberg, Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology, Mannheim, Germany.
⁴ German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany.

Abstract

It has been recently recognized that the tumor microenvironment (TME) is an essential factor that defines the efficiency of chemotherapy. The local TME, consisting of immune cells with diverse phenotypes and functions, can strongly modulate the response to chemotherapy. Tumor-associated macrophages (TAMs) that display pronounced heterogeneity and phenotypic plasticity are the major innate immune component in the microenvironment of solid tumors. In our review, we elucidate the complex role of TAMs in the progression of different types of solid tumors, summarize the current knowledge about the effects of different anticancer chemotherapeutic agents on monocytes/macrophages, and describe the mechanisms of chemotherapy resistance mediated by TAMs.

Keywords: Tumor-associated macrophages; cancer chemotherapy; chemoresistance; immune system; immunomodulation; tumor progression.

Publication types

Review
Research Support, Non-U.S. Gov't

Grants and funding

This work was supported by the Russian Science Foundation under Grand #14-15-00350. The PhD position of Tengfei Liu was supported by the program of China Scholarship Council No.201308130088.