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Asian J Neurosurg. 2019 Apr-Jun;14(2):403-409. doi: 10.4103/ajns.AJNS_152_18.

Predictive Factors for Seizures Accompanying Intracranial Meningiomas.

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1
Department of Neurosurgery, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Abstract

Objective:

Seizures represent a common manifestation of intracranial meningiomas. Their predictive factors before and after excision merit studying.

Materials and Methods:

Patients having intracranial meningioma were prospectively studied. There were two groups; Group "A" with seizures and Group "B" with no preoperative epilepsy.

Results:

This study included 40 patients. Their ages ranged from 40 to 60 years old, and female-to-male ratio was 2.3:1 in both groups. In Group A, partial seizures were the most common pattern (60%). Manifestations other than fits included headache in most patients (97.5%), symptoms of increased intracranial pressure were found in 50% in Group A and 20% in Group B patients, peritumoral edema was present in 14 (70%) patients of Group A, compared to 6 (25%) patients of Group "B." There was a statistically significant relation between peritumoral edema and presentation with fits (P < 0.1). Complication after surgery included nonsurgical hematoma in three patients and contusion in 7 patients. Following surgery for Group "A", 8 (40%) patients had good seizure control. While, in Group "B" 3 (15%), patients developed new-onset seizures. Good seizure control in 7 (53%) patients with frontal, frontotemporal tumors than in other locations. In addition, better control was obtained in left sided, small tumors, and no peritumoral edema. Postoperative complication was significantly associated with new-onset epilepsy and poor seizure control (P < 0.05). Neither tumor size nor location had a significant relation to either pre or postoperative epilepsy.

Conclusion:

Predictive factors for epilepsy accompanying intracranial meningioma included males, elderly patients and patients with small lesions, frontal and left-sided locations but were statistically insignificant predictors. Peritumoral edema and postoperative complications are the most significant predictors.

KEYWORDS:

Epilepsy; excision; lesion; meningioma; peritumoral edema; seizure

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