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J Res Med Sci. 2019 Apr 26;24:35. doi: 10.4103/jrms.JRMS_880_18. eCollection 2019.

Determination of antimicotic susceptibility pattern of Candida species isolated from patients with symptomatic candiduria.

Author information

1
Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
2
Department of Infectious Disease, Rasul-e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
4
Microbiol Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.
5
Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Scienses, Tehran, Iran.
6
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
7
Department of Medical Mycology and Parasitology, School of Medicine, Medical University of Kerman, Kerman, Iran.
8
Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background:

The present study was conducted to determine antimicotic susceptibility of Candida species (sp.) from patients with symptomatic candiduria.

Materials and Methods:

Identification of Candida sp. and determination of efficacy of most routine antifungals were done using polymerase chain reaction-restriction fragment length polymorphism method and E-test, respectively.

Results:

The results from susceptibility test reveal that caspofungin and amphotericin B have high antifungal activity against both albicans (100% and 96%, respectively) and nonalbicans (95.11% and 72.72%, respectively) isolates.

Conclusion:

The present study suggests that caspofungin and amphotericin B have the excellent ability to eradicate both Candida groups that showed decreased susceptibility to other compounds.

KEYWORDS:

Antifungal drugs; Candida species; polymerase chain reaction-restriction fragment length polymorphism; symptomatic candiduria

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