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J Res Med Sci. 2019 Apr 26;24:32. doi: 10.4103/jrms.JRMS_292_18. eCollection 2019.

Regulation of PI3K and Hand2 gene on physiological hypertrophy of heart following high-intensity interval, and endurance training.

Author information

1
Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.
2
Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran.

Abstract

Background:

Physical training signals cardiac hypertrophy through PI3K as an upstream and Hand2 gene as a downstream agent. The present study aimed to find the role of PI3K and Hand2 gene in myocardial hypertrophy following interval and endurance training (ET).

Materials and Methods:

Twenty-four adult Wistar male rats (210-250 g) randomly divided into control, sham, high-intensity interval training (HIIT), and ET group. Swimming time in ET increased incrementally 30-75 min, whereas in HIIT, load/body weight, and time/rest ratio increased within 12 weeks. Heart morphometry, including left ventricle end systolic (LVESV) and Diastolic (LVEDV) volume, LV posterior wall (LVPW), stroke volume (SV), ejection fraction (EF), fraction shortening (%FS), pure heart weight (HW) and left ventricle weight (LVW), and PI3K and Hand2 gene expression were measured.

Results:

HW and LVW were significantly more than control after ET (P < 0.05) and HIIT (P < 0.05). Both of the training groups demonstrated significantly thicker LVPW (P < 0.05), SV (P < 0.05), and %FS (P < 0.05). Furthermore, PI3K concentration and Hand2 expression significantly increased in ET (P < 0.001; P < 0.001, respectively) and HIIT (P < 0.05; P < 0.001, respectively) compared to control.

Conclusion:

It can be concluded that this training protocol caused physiological hypertrophy in both of ET and HIIT groups, whereas HIIT can be more beneficial because of shorter training time.

KEYWORDS:

Endurance training; gene expression; high-intensity interval training; physiological hypertrophy; rat

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